Substrate-Induced Motion between TM4 and TM7 of the Glutamate Transporter EAAT1 Revealed by Paired Cysteine Mutagenesis
نویسندگان
چکیده
منابع مشابه
TM4 of the glutamate transporter GLT-1 experiences substrate-induced motion during the transport cycle
Excitatory amino acid transporter 2 (EAAT2), also known as glial glutamate transporter type 1 (GLT-1), plays an important role in maintaining the extracellular glutamate concentrations below neurotoxic levels. The highly conserved TM2 transmembrane domain of GLT-1 maintains a stable position during the transport cycle; however, the effect of the transport cycle on the topology of TM4 in not wel...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2018
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.118.113183